Tetrandrine enhances the ubiquitination and degradation of Syk through an AhR-c-src-c-Cbl pathway and consequently inhibits osteoclastogenesis and bone destruction in arthritis.
Jia, Yugai
Tetrandrine enhances the ubiquitination and degradation of Syk through an AhR-c-src-c-Cbl pathway and consequently inhibits osteoclastogenesis and bone destruction in arthritis. [electronic resource] - Cell death & disease 01 2019 - 38 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2041-4889
10.1038/s41419-018-1286-2 doi
Antineoplastic Agents, Phytogenic--pharmacology
Arthritis--drug therapy
Benzylisoquinolines--pharmacology
Bone Resorption--drug therapy
Cell Differentiation
Humans
Osteoclasts--metabolism
Osteogenesis--drug effects
Syk Kinase--genetics
Ubiquitination--genetics
Tetrandrine enhances the ubiquitination and degradation of Syk through an AhR-c-src-c-Cbl pathway and consequently inhibits osteoclastogenesis and bone destruction in arthritis. [electronic resource] - Cell death & disease 01 2019 - 38 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2041-4889
10.1038/s41419-018-1286-2 doi
Antineoplastic Agents, Phytogenic--pharmacology
Arthritis--drug therapy
Benzylisoquinolines--pharmacology
Bone Resorption--drug therapy
Cell Differentiation
Humans
Osteoclasts--metabolism
Osteogenesis--drug effects
Syk Kinase--genetics
Ubiquitination--genetics