Improving dermal delivery of hydrophilic macromolecules by biocompatible ionic liquid based on choline and malic acid.

Wu, Xiying

Improving dermal delivery of hydrophilic macromolecules by biocompatible ionic liquid based on choline and malic acid. [electronic resource] - International journal of pharmaceutics Mar 2019 - 380-387 p. digital

Publication Type: Journal Article

1873-3476

10.1016/j.ijpharm.2019.01.021 doi


Administration, Cutaneous
Animals
Cell Line
Cell Survival--drug effects
Choline--administration & dosage
Dextrans--administration & dosage
Fluorescein-5-isothiocyanate--administration & dosage
Humans
Hydrophobic and Hydrophilic Interactions
Ionic Liquids--administration & dosage
Macromolecular Substances--administration & dosage
Malates--administration & dosage
Male
Rats, Sprague-Dawley
Skin--anatomy & histology
Skin Absorption--drug effects
Swine