Curcumin alleviates rheumatoid arthritis-induced inflammation and synovial hyperplasia by targeting mTOR pathway in rats.

Dai, Qiaoding

Curcumin alleviates rheumatoid arthritis-induced inflammation and synovial hyperplasia by targeting mTOR pathway in rats. [electronic resource] - Drug design, development and therapy 2018 - 4095-4105 p. digital

Publication Type: Journal Article

1177-8881

10.2147/DDDT.S175763 doi


Animals
Anti-Inflammatory Agents--pharmacology
Antirheumatic Agents--pharmacology
Arthritis, Experimental--chemically induced
Collagen Type II
Curcumin--pharmacology
Hyperplasia
Inflammation Mediators--metabolism
Interleukin-1beta--metabolism
Male
Matrix Metalloproteinase 1--metabolism
Matrix Metalloproteinase 3--metabolism
Protein Kinase Inhibitors--pharmacology
Proto-Oncogene Proteins c-akt--metabolism
Rats, Wistar
Signal Transduction--drug effects
Sirolimus--pharmacology
Synovial Membrane--drug effects
Synovitis--chemically induced
TOR Serine-Threonine Kinases--antagonists & inhibitors
Tumor Necrosis Factor-alpha--metabolism