Mesenchymal stem cells therapy enhances the efficacy of pregabalin and prevents its motor impairment in paclitaxel-induced neuropathy in rats: Role of Notch1 receptor and JAK/STAT signaling pathway.

Al-Massri, Khaled F

Mesenchymal stem cells therapy enhances the efficacy of pregabalin and prevents its motor impairment in paclitaxel-induced neuropathy in rats: Role of Notch1 receptor and JAK/STAT signaling pathway. [electronic resource] - Behavioural brain research 03 2019 - 303-311 p. digital

Publication Type: Journal Article

1872-7549

10.1016/j.bbr.2018.12.013 doi


Acetone--toxicity
Analysis of Variance
Animals
Antineoplastic Agents, Phytogenic--toxicity
Antioxidants--metabolism
Caspase 3--metabolism
Cell- and Tissue-Based Therapy--methods
Disease Models, Animal
Hyperalgesia--physiopathology
Interleukin-6--metabolism
Janus Kinases--metabolism
Male
Mesenchymal Stem Cells--physiology
Motor Disorders--etiology
Nerve Growth Factor--metabolism
Paclitaxel--toxicity
Pregabalin--therapeutic use
Rats
Rats, Wistar
Receptor, Notch1--metabolism
Rotarod Performance Test
STAT Transcription Factors--metabolism
Sciatic Neuropathy--chemically induced
Time Factors
Tumor Necrosis Factor-alpha--metabolism