Discovery of a highly selective FLT3 inhibitor with specific proliferation inhibition against AML cells harboring FLT3-ITD mutation.

Heng, Hao

Discovery of a highly selective FLT3 inhibitor with specific proliferation inhibition against AML cells harboring FLT3-ITD mutation. [electronic resource] - European journal of medicinal chemistry Feb 2019 - 195-206 p. digital

Publication Type: Journal Article

1768-3254

10.1016/j.ejmech.2018.11.063 doi


Apoptosis--drug effects
Cell Cycle Checkpoints--drug effects
Cell Line
Cell Line, Tumor
Cell Proliferation--drug effects
Drug Discovery
Humans
Leukemia, Myeloid, Acute--drug therapy
Mutation
Protein Kinase Inhibitors--pharmacology
fms-Like Tyrosine Kinase 3--antagonists & inhibitors