HYCO-3, a dual CO-releaser/Nrf2 activator, reduces tissue inflammation in mice challenged with lipopolysaccharide.

Motterlini, Roberto

HYCO-3, a dual CO-releaser/Nrf2 activator, reduces tissue inflammation in mice challenged with lipopolysaccharide. [electronic resource] - Redox biology 01 2019 - 334-348 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

2213-2317

10.1016/j.redox.2018.10.020 doi


Animals
Anti-Inflammatory Agents--pharmacology
Antioxidants--metabolism
Carbon Monoxide--metabolism
Cells, Cultured
Cytokines--genetics
Disease Models, Animal
Gene Expression
Heme Oxygenase-1--genetics
Inflammation--drug therapy
Inflammation Mediators--metabolism
Lipopolysaccharides--adverse effects
Macrophages--drug effects
Male
Mice
Mice, Knockout
Microglia--drug effects
NF-E2-Related Factor 2--genetics
Oxidative Stress--drug effects