Metabolic profiling of copper-laden hepatolenticular degeneration model rats and the interventional effects of Gandou decoction using UPLC-Q-TOF/MS.

Cheng, Meimei

Metabolic profiling of copper-laden hepatolenticular degeneration model rats and the interventional effects of Gandou decoction using UPLC-Q-TOF/MS. [electronic resource] - Journal of pharmaceutical and biomedical analysis Feb 2019 - 187-195 p. digital

Publication Type: Journal Article

1873-264X

10.1016/j.jpba.2018.10.041 doi


Amino Acids--metabolism
Animals
Biomarkers--blood
Chromatography, High Pressure Liquid--instrumentation
Copper Sulfate--toxicity
Disease Models, Animal
Drugs, Chinese Herbal--pharmacology
Glucose--metabolism
Hepatolenticular Degeneration--chemically induced
Humans
Lipid Metabolism--drug effects
Liver--drug effects
Male
Metabolic Networks and Pathways--drug effects
Metabolome--drug effects
Metabolomics--instrumentation
Multivariate Analysis
Principal Component Analysis
Rats
Tandem Mass Spectrometry--instrumentation
Treatment Outcome