HMGB1 promotes ERK-mediated mitochondrial Drp1 phosphorylation for chemoresistance through RAGE in colorectal cancer.

Huang, Chih-Yang

HMGB1 promotes ERK-mediated mitochondrial Drp1 phosphorylation for chemoresistance through RAGE in colorectal cancer. [electronic resource] - Cell death & disease 09 2018 - 1004 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

2041-4889

10.1038/s41419-018-1019-6 doi


Animals
Antigens, Neoplasm--genetics
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Autophagy--drug effects
Cell Line, Tumor
Colorectal Neoplasms--drug therapy
Disease-Free Survival
Drug Resistance, Neoplasm--genetics
Dynamins
GTP Phosphohydrolases--genetics
HMGB1 Protein--genetics
Humans
MAP Kinase Signaling System--drug effects
Mice
Mice, Inbred BALB C
Mice, Nude
Microtubule-Associated Proteins--genetics
Mitochondria--drug effects
Mitochondrial Dynamics--drug effects
Mitochondrial Proteins--genetics
Mitogen-Activated Protein Kinases--genetics
Phosphorylation--drug effects
RNA Interference--drug effects
Rectal Neoplasms--drug therapy
Tumor Microenvironment--drug effects