Metabolism of the beta-carbolines, harmine and harmol, by liver microsomes from phenobarbitone- or 3-methylcholanthrene-treated mice. Identification and quantitation of two novel harmine metabolites.

Tweedie, D J

Metabolism of the beta-carbolines, harmine and harmol, by liver microsomes from phenobarbitone- or 3-methylcholanthrene-treated mice. Identification and quantitation of two novel harmine metabolites. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals - 74-81 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0090-9556


Alkaloids--metabolism
Animals
Chromatography, High Pressure Liquid
Enzyme Induction--drug effects
Harmine--analogs & derivatives
Magnetic Resonance Spectroscopy
Male
Mass Spectrometry
Methylcholanthrene--pharmacology
Mice
Mice, Inbred C57BL
Microsomes, Liver--metabolism
Phenobarbital--pharmacology
Protein Binding