Type I IFN signaling blockade by a PASylated antagonist during chronic SIV infection suppresses specific inflammatory pathways but does not alter T cell activation or virus replication.
Nganou-Makamdop, Krystelle
Type I IFN signaling blockade by a PASylated antagonist during chronic SIV infection suppresses specific inflammatory pathways but does not alter T cell activation or virus replication. [electronic resource] - PLoS pathogens 08 2018 - e1007246 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
1553-7374
10.1371/journal.ppat.1007246 doi
Animals
Anti-Retroviral Agents--pharmacology
Chronic Disease
Inflammation--immunology
Interferon Type I--antagonists & inhibitors
Lymphocyte Activation--drug effects
Macaca mulatta
Receptors, Interferon--antagonists & inhibitors
Signal Transduction--drug effects
Simian Acquired Immunodeficiency Syndrome--drug therapy
Simian Immunodeficiency Virus--drug effects
T-Lymphocytes--drug effects
Virus Replication--drug effects
Type I IFN signaling blockade by a PASylated antagonist during chronic SIV infection suppresses specific inflammatory pathways but does not alter T cell activation or virus replication. [electronic resource] - PLoS pathogens 08 2018 - e1007246 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
1553-7374
10.1371/journal.ppat.1007246 doi
Animals
Anti-Retroviral Agents--pharmacology
Chronic Disease
Inflammation--immunology
Interferon Type I--antagonists & inhibitors
Lymphocyte Activation--drug effects
Macaca mulatta
Receptors, Interferon--antagonists & inhibitors
Signal Transduction--drug effects
Simian Acquired Immunodeficiency Syndrome--drug therapy
Simian Immunodeficiency Virus--drug effects
T-Lymphocytes--drug effects
Virus Replication--drug effects