Inhibition of spinal 15-LOX-1 attenuates TLR4-dependent, nonsteroidal anti-inflammatory drug-unresponsive hyperalgesia in male rats.

Gregus, Ann M

Inhibition of spinal 15-LOX-1 attenuates TLR4-dependent, nonsteroidal anti-inflammatory drug-unresponsive hyperalgesia in male rats. [electronic resource] - Pain Dec 2018 - 2620-2629 p. digital

Publication Type: Journal Article

1872-6623

10.1097/j.pain.0000000000001373 doi


8,11,14-Eicosatrienoic Acid--analogs & derivatives
Animals
Animals, Newborn
Anti-Inflammatory Agents, Non-Steroidal--therapeutic use
Cells, Cultured
Chromatography, Liquid
Enzyme Inhibitors--therapeutic use
Hyperalgesia--drug therapy
Lipopolysaccharides--toxicity
Lipoxygenases--therapeutic use
Male
Mass Spectrometry
Neuroglia--drug effects
Physical Stimulation--adverse effects
RNA, Messenger
Rats
Rats, Sprague-Dawley
Spinal Cord--cytology
Toll-Like Receptor 4--antagonists & inhibitors
Transfection