Berberine ameliorates blockade of autophagic flux in the liver by regulating cholesterol metabolism and inhibiting COX2-prostaglandin synthesis.

Sun, Haidong

Berberine ameliorates blockade of autophagic flux in the liver by regulating cholesterol metabolism and inhibiting COX2-prostaglandin synthesis. [electronic resource] - Cell death & disease 08 2018 - 824 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

2041-4889

10.1038/s41419-018-0890-5 doi


Animals
Autophagy--drug effects
Berberine--pharmacology
Cholesterol--metabolism
Cyclooxygenase 2--chemistry
Diet, High-Fat
Hep G2 Cells
Humans
Liver--drug effects
Male
Mice
Microtubule-Associated Proteins--genetics
Phosphorylation--drug effects
Prostaglandins--metabolism
Proto-Oncogene Proteins c-akt--metabolism
Sequestosome-1 Protein--metabolism
TOR Serine-Threonine Kinases--metabolism