Spatio-temporal visualization of the distribution of acetaminophen as well as its metabolites and adducts in mouse livers by MALDI MSI.

Sezgin, Selahaddin

Spatio-temporal visualization of the distribution of acetaminophen as well as its metabolites and adducts in mouse livers by MALDI MSI. [electronic resource] - Archives of toxicology 09 2018 - 2963-2977 p. digital

Publication Type: Journal Article

1432-0738

10.1007/s00204-018-2271-3 doi


Acetaminophen--administration & dosage
Animals
Benzoquinones--metabolism
Cytochrome P-450 CYP2E1--metabolism
Dose-Response Relationship, Drug
Glutathione--metabolism
Imines--metabolism
Liver--drug effects
Male
Mice, Inbred C57BL
Spatio-Temporal Analysis
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization--methods