Epidermal growth factor (EGF) and hormones stimulate phosphoinositide hydrolysis and increase EGF receptor protein synthesis and mRNA levels in rat liver epithelial cells. Evidence for protein kinase C-dependent and -independent pathways.

Earp, H S

Epidermal growth factor (EGF) and hormones stimulate phosphoinositide hydrolysis and increase EGF receptor protein synthesis and mRNA levels in rat liver epithelial cells. Evidence for protein kinase C-dependent and -independent pathways. [electronic resource] - The Journal of biological chemistry Sep 1988 - 13868-74 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0021-9258


Angiotensin II--pharmacology
Animals
Arginine Vasopressin--pharmacology
Cell Line
Enzyme Activation
Epidermal Growth Factor--pharmacology
Epinephrine--pharmacology
Epithelium--drug effects
ErbB Receptors--biosynthesis
Hydrolysis
Inositol--metabolism
Inositol Phosphates--metabolism
Kinetics
Liver--drug effects
Phosphatidylinositol 4,5-Diphosphate
Phosphatidylinositols--metabolism
Protein Kinase C--metabolism
RNA, Messenger--biosynthesis
Rats
Tetradecanoylphorbol Acetate--pharmacology