A tutorial on model informed approaches to cardiovascular safety with focus on cardiac repolarisation.

Cheung, S Y A

A tutorial on model informed approaches to cardiovascular safety with focus on cardiac repolarisation. [electronic resource] - Journal of pharmacokinetics and pharmacodynamics 06 2018 - 365-381 p. digital

Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't

1573-8744

10.1007/s10928-018-9589-6 doi


Animals
Blood Pressure--drug effects
Cardiovascular Diseases--chemically induced
Cardiovascular System--drug effects
Dogs
Drug Discovery--methods
Drug Evaluation, Preclinical
Drug-Related Side Effects and Adverse Reactions--etiology
Guinea Pigs
Heart Rate--drug effects
Humans
Macaca mulatta
Pharmaceutical Preparations--administration & dosage
Rabbits
Rats