Aminoguanidine Hydrazone Derivatives as Nonpeptide NPFF1 Receptor Antagonists Reverse Opioid Induced Hyperalgesia.

Hammoud, Hassan

Aminoguanidine Hydrazone Derivatives as Nonpeptide NPFF1 Receptor Antagonists Reverse Opioid Induced Hyperalgesia. [electronic resource] - ACS chemical neuroscience 11 2018 - 2599-2609 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1948-7193

10.1021/acschemneuro.8b00099 doi


Analgesics, Opioid--adverse effects
Animals
Drug Tolerance
Guanidines--pharmacology
Hydrazones--pharmacology
Hyperalgesia--chemically induced
Male
Mice
Nociception--drug effects
Rats
Rats, Sprague-Dawley
Receptors, Neuropeptide--antagonists & inhibitors
Structure-Activity Relationship