A Rationally Designed Fully Human EGFRvIII:CD3-Targeted Bispecific Antibody Redirects Human T Cells to Treat Patient-derived Intracerebral Malignant Glioma.
Gedeon, Patrick C
A Rationally Designed Fully Human EGFRvIII:CD3-Targeted Bispecific Antibody Redirects Human T Cells to Treat Patient-derived Intracerebral Malignant Glioma. [electronic resource] - Clinical cancer research : an official journal of the American Association for Cancer Research 08 2018 - 3611-3631 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1557-3265
10.1158/1078-0432.CCR-17-0126 doi
Animals
Antibodies, Bispecific--pharmacology
CD3 Complex--antagonists & inhibitors
Cell Line, Tumor
ErbB Receptors--antagonists & inhibitors
Female
Gene Expression Regulation, Neoplastic--immunology
Glioma--drug therapy
Humans
Immunotherapy
Lymphocyte Activation--drug effects
Male
Mice
Recombinant Proteins--genetics
Single-Chain Antibodies--immunology
T-Lymphocytes--drug effects
Xenograft Model Antitumor Assays
A Rationally Designed Fully Human EGFRvIII:CD3-Targeted Bispecific Antibody Redirects Human T Cells to Treat Patient-derived Intracerebral Malignant Glioma. [electronic resource] - Clinical cancer research : an official journal of the American Association for Cancer Research 08 2018 - 3611-3631 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1557-3265
10.1158/1078-0432.CCR-17-0126 doi
Animals
Antibodies, Bispecific--pharmacology
CD3 Complex--antagonists & inhibitors
Cell Line, Tumor
ErbB Receptors--antagonists & inhibitors
Female
Gene Expression Regulation, Neoplastic--immunology
Glioma--drug therapy
Humans
Immunotherapy
Lymphocyte Activation--drug effects
Male
Mice
Recombinant Proteins--genetics
Single-Chain Antibodies--immunology
T-Lymphocytes--drug effects
Xenograft Model Antitumor Assays