SPAG5 promotes proliferation and suppresses apoptosis in bladder urothelial carcinoma by upregulating Wnt3 via activating the AKT/mTOR pathway and predicts poorer survival.

Liu, J Y

SPAG5 promotes proliferation and suppresses apoptosis in bladder urothelial carcinoma by upregulating Wnt3 via activating the AKT/mTOR pathway and predicts poorer survival. [electronic resource] - Oncogene 07 2018 - 3937-3952 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1476-5594

10.1038/s41388-018-0223-2 doi


Apoptosis--genetics
Carcinoma--genetics
Cell Cycle Proteins--genetics
Cell Line, Tumor
Cell Proliferation--genetics
Cohort Studies
Cystectomy--methods
Down-Regulation--genetics
Humans
Proto-Oncogene Proteins c-akt--genetics
Signal Transduction--genetics
TOR Serine-Threonine Kinases--genetics
Up-Regulation--genetics
Urinary Bladder Neoplasms--genetics
Wnt3 Protein--genetics