Elevated MeCP2 in Mice Causes Neurodegeneration Involving Tau Dysregulation and Excitotoxicity: Implications for the Understanding and Treatment of MeCP2 Triplication Syndrome.

Montgomery, Kristen R

Elevated MeCP2 in Mice Causes Neurodegeneration Involving Tau Dysregulation and Excitotoxicity: Implications for the Understanding and Treatment of MeCP2 Triplication Syndrome. [electronic resource] - Molecular neurobiology Dec 2018 - 9057-9074 p. digital

Publication Type: Journal Article

1559-1182

10.1007/s12035-018-1046-4 doi


Animals
Apoptosis--drug effects
Astrocytes--drug effects
Brain--metabolism
Caspase 3--metabolism
Culture Media, Conditioned--pharmacology
Female
Gene Expression Regulation--drug effects
Male
Methyl-CpG-Binding Protein 2--metabolism
Mice, Transgenic
Models, Biological
Nerve Degeneration--genetics
Nerve Tissue Proteins--metabolism
Neurons--drug effects
Neurotoxins--toxicity
RNA, Messenger--genetics
Spinal Cord--metabolism
Syndrome
Up-Regulation--drug effects
tau Proteins--metabolism