In Vitro Negative Inotropic Effect of Low Concentrations of Bupivacaine Relates to Diminished Ca2+ Sensitivity but Not to Ca2+ Handling or β-Adrenoceptor Signaling.

Flenner, Frederik

In Vitro Negative Inotropic Effect of Low Concentrations of Bupivacaine Relates to Diminished Ca2+ Sensitivity but Not to Ca2+ Handling or β-Adrenoceptor Signaling. [electronic resource] - Anesthesiology 06 2018 - 1175-1186 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1528-1175

10.1097/ALN.0000000000002180 doi


Anesthetics, Local--administration & dosage
Animals
Bupivacaine--administration & dosage
Calcium--metabolism
Cells, Cultured
Dose-Response Relationship, Drug
Guinea Pigs
Male
Mice
Myocardial Contraction--drug effects
Myocytes, Cardiac--drug effects
Organ Culture Techniques
Receptors, Adrenergic, beta--physiology