Neonatal hyperglycemia induces CXCL10/CXCR3 signaling and microglial activation and impairs long-term synaptogenesis in the hippocampus and alters behavior in rats.

Satrom, Katherine M

Neonatal hyperglycemia induces CXCL10/CXCR3 signaling and microglial activation and impairs long-term synaptogenesis in the hippocampus and alters behavior in rats. [electronic resource] - Journal of neuroinflammation Mar 2018 - 82 p. digital

Publication Type: Journal Article

1742-2094

10.1186/s12974-018-1121-9 doi


Age Factors
Animals
Animals, Newborn
Antibiotics, Antineoplastic--toxicity
CD11 Antigens--metabolism
Chemokine CXCL10--metabolism
Developmental Disabilities--etiology
Disks Large Homolog 4 Protein--metabolism
Encephalitis--etiology
Female
Hippocampus--pathology
Hyperglycemia--chemically induced
Male
Maze Learning
Microglia--drug effects
Microtubule-Associated Proteins--metabolism
Oxidative Stress--drug effects
Rats
Rats, Wistar
Receptors, CXCR3--metabolism
Signal Transduction--drug effects
Streptozocin--toxicity
Synapses--drug effects