The cryoprotectant trehalose could inhibit ERS-induced apoptosis by activating autophagy in cryoprotected rat valves.

Wu, Hongyan

The cryoprotectant trehalose could inhibit ERS-induced apoptosis by activating autophagy in cryoprotected rat valves. [electronic resource] - PloS one 2018 - e0194078 p. digital

Publication Type: Comparative Study; Journal Article; Retracted Publication

1932-6203

10.1371/journal.pone.0194078 doi


Animals
Aortic Valve--cytology
Apoptosis--drug effects
Apoptosis Regulatory Proteins--analysis
Autophagy--drug effects
Cryopreservation--methods
Cryoprotective Agents--pharmacology
Dimethyl Sulfoxide--pharmacology
Endoplasmic Reticulum Stress--drug effects
Glucose--metabolism
MAP Kinase Signaling System--drug effects
Male
Malondialdehyde--analysis
MicroRNAs--analysis
Rats
Rats, Sprague-Dawley
TOR Serine-Threonine Kinases--physiology
Trehalose--pharmacology