Design of Highly Potent, Dual-Acting and Central-Nervous-System-Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants.

Ghosh, Arun K

Design of Highly Potent, Dual-Acting and Central-Nervous-System-Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants. [electronic resource] - ChemMedChem 04 2018 - 803-815 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

1860-7187

10.1002/cmdc.201700824 doi


Animals
Brain--metabolism
Carbamates--chemistry
Cell Line
Crystallography, X-Ray
Drug Design
HIV Infections--drug therapy
HIV Protease--chemistry
HIV Protease Inhibitors--chemistry
HIV-1--chemistry
Halogenation
Humans
Models, Molecular
Rats