Acidic organelles mediate TGF-β1-induced cellular fibrosis via (pro)renin receptor and vacuolar ATPase trafficking in human peritoneal mesothelial cells.

Oba-Yabana, Ikuko

Acidic organelles mediate TGF-β1-induced cellular fibrosis via (pro)renin receptor and vacuolar ATPase trafficking in human peritoneal mesothelial cells. [electronic resource] - Scientific reports 02 2018 - 2648 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

2045-2322

10.1038/s41598-018-20940-x doi


Aged
Animals
Cell Movement--drug effects
Dialysis Solutions--metabolism
Epithelium--metabolism
Female
Fibrosis--metabolism
Glucose--metabolism
Humans
Hydrogen-Ion Concentration
Kidney--metabolism
Male
Middle Aged
Organelles--metabolism
Peritoneal Cavity--physiology
Peritoneal Dialysis--adverse effects
Peritoneal Fibrosis--metabolism
Peritoneum--metabolism
Protein Transport
Rats
Rats, Wistar
Receptors, Cell Surface--metabolism
Renin--metabolism
Transforming Growth Factor beta1--metabolism
Vacuolar Proton-Translocating ATPases--metabolism