Dose reduction of bone morphogenetic protein-2 for bone regeneration using a delivery system based on lyophilization with trehalose.

Zhang, Xiaochen

Dose reduction of bone morphogenetic protein-2 for bone regeneration using a delivery system based on lyophilization with trehalose. [electronic resource] - International journal of nanomedicine 2018 - 403-414 p. digital

Publication Type: Journal Article

1178-2013

10.2147/IJN.S150875 doi


Animals
Bone Morphogenetic Protein 2--pharmacology
Bone Regeneration--drug effects
Cell Differentiation--drug effects
Cell Proliferation--drug effects
Dose-Response Relationship, Drug
Drug Delivery Systems
Drug Liberation
Freeze Drying
Male
Mesenchymal Stem Cells--cytology
Nanotubes--chemistry
Osteogenesis--drug effects
Rats, Inbred F344
Titanium--chemistry
Trehalose--chemistry
X-Ray Microtomography