The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53.

Madan, Esha

The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53. [electronic resource] - The Journal of biological chemistry 03 2018 - 4262-4276 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1083-351X

10.1074/jbc.RA117.000950 doi


Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Cell Proliferation--drug effects
Curcumin--analogs & derivatives
Female
Humans
Mice
Mice, Nude
Mutant Proteins--genetics
Mutation
Neoplasms--drug therapy
Piperidones--pharmacology
Tumor Cells, Cultured
Tumor Suppressor Protein p53--genetics
Xenograft Model Antitumor Assays