Discovery and Characterization of CD12681, a Potent RORγ Inverse Agonist, Preclinical Candidate for the Topical Treatment of Psoriasis.
Ouvry, Gilles
Discovery and Characterization of CD12681, a Potent RORγ Inverse Agonist, Preclinical Candidate for the Topical Treatment of Psoriasis. [electronic resource] - ChemMedChem 02 2018 - 321-337 p. digital
Publication Type: Journal Article
1860-7187
10.1002/cmdc.201700758 doi
Administration, Topical
Animals
Disease Models, Animal
Drug Evaluation, Preclinical
Drug Inverse Agonism
Humans
Inhibitory Concentration 50
Interleukin-17--metabolism
Interleukin-23--pharmacology
Keratinocytes--cytology
Mice
Mice, Inbred BALB C
Nuclear Receptor Subfamily 1, Group F, Member 3--agonists
Psoriasis--drug therapy
Skin Diseases--chemically induced
Structure-Activity Relationship
Sulfonamides--chemistry
Th17 Cells--cytology
Discovery and Characterization of CD12681, a Potent RORγ Inverse Agonist, Preclinical Candidate for the Topical Treatment of Psoriasis. [electronic resource] - ChemMedChem 02 2018 - 321-337 p. digital
Publication Type: Journal Article
1860-7187
10.1002/cmdc.201700758 doi
Administration, Topical
Animals
Disease Models, Animal
Drug Evaluation, Preclinical
Drug Inverse Agonism
Humans
Inhibitory Concentration 50
Interleukin-17--metabolism
Interleukin-23--pharmacology
Keratinocytes--cytology
Mice
Mice, Inbred BALB C
Nuclear Receptor Subfamily 1, Group F, Member 3--agonists
Psoriasis--drug therapy
Skin Diseases--chemically induced
Structure-Activity Relationship
Sulfonamides--chemistry
Th17 Cells--cytology