Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases.
Vazquez, Michael L
Identification of N-propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases. [electronic resource] - Journal of medicinal chemistry 02 2018 - 1130-1152 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1520-4804
10.1021/acs.jmedchem.7b01598 doi
Animals
Arthritis, Experimental--drug therapy
Autoimmune Diseases--drug therapy
Cyclobutanes--chemistry
Dogs
Drug Evaluation, Preclinical
Humans
Inhibitory Concentration 50
Janus Kinase 1--antagonists & inhibitors
Janus Kinase 2--antagonists & inhibitors
Models, Molecular
Protein Conformation
Protein Kinase Inhibitors--chemistry
Pyrimidines--chemistry
Pyrroles--chemistry
Rats
Substrate Specificity
Sulfonamides--chemistry
Tissue Distribution
Identification of N-propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases. [electronic resource] - Journal of medicinal chemistry 02 2018 - 1130-1152 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1520-4804
10.1021/acs.jmedchem.7b01598 doi
Animals
Arthritis, Experimental--drug therapy
Autoimmune Diseases--drug therapy
Cyclobutanes--chemistry
Dogs
Drug Evaluation, Preclinical
Humans
Inhibitory Concentration 50
Janus Kinase 1--antagonists & inhibitors
Janus Kinase 2--antagonists & inhibitors
Models, Molecular
Protein Conformation
Protein Kinase Inhibitors--chemistry
Pyrimidines--chemistry
Pyrroles--chemistry
Rats
Substrate Specificity
Sulfonamides--chemistry
Tissue Distribution