Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity.

Zhang, Yuan

Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity. [electronic resource] - Nature communications 01 2018 - 6 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

2041-1723

10.1038/s41467-017-02251-3 doi


Animals
Antineoplastic Agents--pharmacology
Cell Line, Tumor
Cytokines--drug effects
Drug Delivery Systems
Granzymes--drug effects
Interleukin-2--pharmacology
Killer Cells, Natural--drug effects
Liposomes
Lymphocytes, Tumor-Infiltrating--drug effects
Melanoma, Experimental
Mice
Nanoparticles
Skin Neoplasms
T-Lymphocytes, Cytotoxic--drug effects
Tumor Microenvironment--drug effects
Tumor Necrosis Factor Receptor Superfamily, Member 9--agonists