First-in-Class ERK1/2 Inhibitor Ulixertinib (BVD-523) in Patients with MAPK Mutant Advanced Solid Tumors: Results of a Phase I Dose-Escalation and Expansion Study.

Sullivan, Ryan J

First-in-Class ERK1/2 Inhibitor Ulixertinib (BVD-523) in Patients with MAPK Mutant Advanced Solid Tumors: Results of a Phase I Dose-Escalation and Expansion Study. [electronic resource] - Cancer discovery 02 2018 - 184-195 p. digital

Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't

2159-8290

10.1158/2159-8290.CD-17-1119 doi


Adult
Aged
Aged, 80 and over
Aminopyridines--pharmacology
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Mitogen-Activated Protein Kinase 1--antagonists & inhibitors
Mitogen-Activated Protein Kinase 3--antagonists & inhibitors
Mitogen-Activated Protein Kinases--genetics
Mutation
Neoplasm Staging
Neoplasms--diagnosis
Protein Kinase Inhibitors--pharmacology
Pyrroles--pharmacology
Tomography, X-Ray Computed
Treatment Outcome
Young Adult