Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis.

Lagares, David

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis. [electronic resource] - Science translational medicine Dec 2017

Publication Type: Journal Article

1946-6242

10.1126/scitranslmed.aal3765 doi


Aniline Compounds--pharmacology
Animals
Apoptosis--drug effects
Biomechanical Phenomena
Cell Survival--drug effects
Dermis--pathology
Disease Models, Animal
Extracellular Matrix--metabolism
Fibrosis
Humans
Male
Mechanotransduction, Cellular--drug effects
Mice, Inbred C57BL
Mitochondria--drug effects
Mitochondrial Membranes--drug effects
Myofibroblasts--drug effects
Scleroderma, Systemic--pathology
Signal Transduction--drug effects
Sulfonamides--pharmacology
bcl-X Protein--metabolism