Design and Synthesis of Orally Bioavailable Piperazine Substituted 4(1H)-Quinolones with Potent Antimalarial Activity: Structure-Activity and Structure-Property Relationship Studies.

Neelarapu, Raghupathi

Design and Synthesis of Orally Bioavailable Piperazine Substituted 4(1H)-Quinolones with Potent Antimalarial Activity: Structure-Activity and Structure-Property Relationship Studies. [electronic resource] - Journal of medicinal chemistry 02 2018 - 1450-1473 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1520-4804

10.1021/acs.jmedchem.7b00738 doi


Animals
Antimalarials--chemical synthesis
Drug Design
Humans
Mice
Piperazine--chemistry
Plasmodium falciparum--drug effects
Quinolones--chemistry
Solubility
Structure-Activity Relationship