Hypoxia and hypoxia-inducible factor (HIF) downregulate antigen-presenting MHC class I molecules limiting tumor cell recognition by T cells.
Sethumadhavan, Shalini
Hypoxia and hypoxia-inducible factor (HIF) downregulate antigen-presenting MHC class I molecules limiting tumor cell recognition by T cells. [electronic resource] - PloS one 2017 - e0187314 p. digital
Publication Type: Journal Article
1932-6203
10.1371/journal.pone.0187314 doi
ATP Binding Cassette Transporter, Subfamily B, Member 2--genetics
Antigen-Presenting Cells--immunology
Cell Hypoxia--immunology
Gene Expression Regulation, Neoplastic
Genes, MHC Class I--immunology
Humans
Hypoxia-Inducible Factor 1--genetics
Kidney Neoplasms--genetics
Oxygen--metabolism
Proteasome Endopeptidase Complex--genetics
T-Lymphocytes--immunology
Transcriptional Activation--genetics
Tumor Microenvironment--genetics
Von Hippel-Lindau Tumor Suppressor Protein--genetics
Hypoxia and hypoxia-inducible factor (HIF) downregulate antigen-presenting MHC class I molecules limiting tumor cell recognition by T cells. [electronic resource] - PloS one 2017 - e0187314 p. digital
Publication Type: Journal Article
1932-6203
10.1371/journal.pone.0187314 doi
ATP Binding Cassette Transporter, Subfamily B, Member 2--genetics
Antigen-Presenting Cells--immunology
Cell Hypoxia--immunology
Gene Expression Regulation, Neoplastic
Genes, MHC Class I--immunology
Humans
Hypoxia-Inducible Factor 1--genetics
Kidney Neoplasms--genetics
Oxygen--metabolism
Proteasome Endopeptidase Complex--genetics
T-Lymphocytes--immunology
Transcriptional Activation--genetics
Tumor Microenvironment--genetics
Von Hippel-Lindau Tumor Suppressor Protein--genetics