Calcineurin inhibitor-induced complement system activation via ERK1/2 signalling is inhibited by SOCS-3 in human renal tubule cells.

Loeschenberger, Beatrix

Calcineurin inhibitor-induced complement system activation via ERK1/2 signalling is inhibited by SOCS-3 in human renal tubule cells. [electronic resource] - European journal of immunology 02 2018 - 330-343 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1521-4141

10.1002/eji.201747135 doi


Aged
Aged, 80 and over
Apoptosis
CD55 Antigens--metabolism
Calcineurin Inhibitors--adverse effects
Cell Line
Cell Survival
Complement Membrane Attack Complex--metabolism
Complement System Proteins--metabolism
Cyclosporine--adverse effects
Drug-Related Side Effects and Adverse Reactions--metabolism
Female
Gene Expression Regulation
Graft Rejection--metabolism
Humans
Kidney Diseases--metabolism
Kidney Transplantation
Kidney Tubules--drug effects
MAP Kinase Signaling System
Male
Membrane Cofactor Protein--metabolism
Middle Aged
Phosphorylation
RNA, Small Interfering--genetics
Suppressor of Cytokine Signaling 3 Protein--genetics
Tacrolimus--adverse effects