Determining a threshold sub-acute dose leading to minimal physiological alterations following prolonged exposure to the nerve agent VX in rats.

Bloch-Shilderman, E

Determining a threshold sub-acute dose leading to minimal physiological alterations following prolonged exposure to the nerve agent VX in rats. [electronic resource] - Archives of toxicology Feb 2018 - 873-892 p. digital

Publication Type: Journal Article

1432-0738

10.1007/s00204-017-2108-5 doi


Animals
Biomarkers--blood
Body Temperature
Body Weight
Brain--drug effects
Carrier Proteins--metabolism
Chemical Warfare Agents--toxicity
Cholinesterase Inhibitors--toxicity
Cholinesterases--blood
Dose-Response Relationship, Drug
Male
Motor Activity
Muscles--drug effects
Nerve Agents--toxicity
Organothiophosphorus Compounds--toxicity
Rats
Rats, Sprague-Dawley
Receptor, Muscarinic M2--metabolism
Receptors, GABA-A--metabolism
Toxicity Tests, Chronic