Substitution of Yor1p NBD1 residues improves the thermal stability of Human Cystic Fibrosis Transmembrane Conductance Regulator.

Xavier, B M

Substitution of Yor1p NBD1 residues improves the thermal stability of Human Cystic Fibrosis Transmembrane Conductance Regulator. [electronic resource] - Protein engineering, design & selection : PEDS Oct 2017 - 729-741 p. digital

Publication Type: Journal Article

1741-0134

10.1093/protein/gzx054 doi


ATP-Binding Cassette Transporters--chemistry
Amino Acid Sequence
Amino Acid Substitution
Animals
Binding Sites
CHO Cells
Cricetulus
Cystic Fibrosis Transmembrane Conductance Regulator--chemistry
Endoplasmic Reticulum--metabolism
Genetic Vectors--chemistry
Hot Temperature
Humans
Models, Molecular
Mutant Chimeric Proteins--chemistry
Protein Binding
Protein Conformation, alpha-Helical
Protein Conformation, beta-Strand
Protein Folding
Protein Interaction Domains and Motifs
Protein Stability
Saccharomyces cerevisiae--genetics
Saccharomyces cerevisiae Proteins--chemistry
Sequence Alignment
Sequence Homology, Amino Acid
Structure-Activity Relationship