Predictive Performance of Physiologically Based Pharmacokinetic (PBPK) Modeling of Drugs Extensively Metabolized by Major Cytochrome P450s in Children.

Zhou, Wangda

Predictive Performance of Physiologically Based Pharmacokinetic (PBPK) Modeling of Drugs Extensively Metabolized by Major Cytochrome P450s in Children. [electronic resource] - Clinical pharmacology and therapeutics 07 2018 - 188-200 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1532-6535

10.1002/cpt.905 doi


Acetates--metabolism
Analgesics, Opioid--metabolism
Anti-Asthmatic Agents--metabolism
Anti-Inflammatory Agents, Non-Steroidal--metabolism
Antifungal Agents--metabolism
Bronchodilator Agents--metabolism
Child
Child, Preschool
Cyclopropanes
Cytochrome P-450 CYP1A2--metabolism
Cytochrome P-450 CYP2C19--metabolism
Cytochrome P-450 CYP2C8--metabolism
Cytochrome P-450 CYP2C9--metabolism
Cytochrome P-450 CYP2D6--metabolism
Cytochrome P-450 CYP3A--metabolism
Cytochrome P-450 Enzyme System--metabolism
Diclofenac--metabolism
Esomeprazole--metabolism
Histamine H1 Antagonists, Non-Sedating--metabolism
Humans
Infant
Infant, Newborn
Itraconazole--metabolism
Lansoprazole--metabolism
Loratadine--analogs & derivatives
Models, Biological
Ondansetron--metabolism
Pharmaceutical Preparations--metabolism
Pharmacokinetics
Proton Pump Inhibitors--metabolism
Quinolines--metabolism
Serotonin Antagonists--metabolism
Sufentanil--metabolism
Sulfides
Theophylline--metabolism
Tramadol--metabolism