Neurodevelopment and Thyroid Hormone Synthesis Inhibition in the Rat: Quantitative Understanding Within the Adverse Outcome Pathway Framework.

Hassan, Iman

Neurodevelopment and Thyroid Hormone Synthesis Inhibition in the Rat: Quantitative Understanding Within the Adverse Outcome Pathway Framework. [electronic resource] - Toxicological sciences : an official journal of the Society of Toxicology Nov 2017 - 57-73 p. digital

Publication Type: Journal Article

1096-0929

10.1093/toxsci/kfx163 doi


Adverse Outcome Pathways
Animals
Biomarkers--blood
Brain--abnormalities
Computer Simulation
Dose-Response Relationship, Drug
Endocrine Disruptors--toxicity
Enzyme Inhibitors--toxicity
Female
Gestational Age
Iodide Peroxidase--antagonists & inhibitors
Malformations of Cortical Development--chemically induced
Maternal Exposure--adverse effects
Pregnancy
Prenatal Exposure Delayed Effects
Propylthiouracil--toxicity
Rats, Long-Evans
Thyroid Gland--drug effects
Thyroxine--biosynthesis
Time Factors