Didox (3,4-dihydroxybenzohydroxamic acid) suppresses IgE-mediated mast cell activation through attenuation of NFκB and AP-1 transcription.

McLeod, Jamie Josephine Avila

Didox (3,4-dihydroxybenzohydroxamic acid) suppresses IgE-mediated mast cell activation through attenuation of NFκB and AP-1 transcription. [electronic resource] - Cellular immunology Dec 2017 - 41-48 p. digital

Publication Type: Journal Article

1090-2163

10.1016/j.cellimm.2017.09.008 doi


Acetylcysteine--pharmacology
Animals
Anti-Inflammatory Agents--pharmacology
Antioxidants--pharmacology
Bone Marrow Cells--immunology
Catalase--biosynthesis
Cell Degranulation--drug effects
Cells, Cultured
Chemokine CCL3--biosynthesis
Hydroxamic Acids--pharmacology
Hypersensitivity--drug therapy
Immunoglobulin E--immunology
Interleukin-13--biosynthesis
Interleukin-6--biosynthesis
Mast Cells--drug effects
Mice
Mice, Inbred C57BL
NF-kappa B--genetics
Oxidative Stress--drug effects
Reactive Oxygen Species--metabolism
Superoxide Dismutase--biosynthesis
Transcription Factor AP-1--genetics
Transcription, Genetic--drug effects
Tumor Necrosis Factor-alpha--biosynthesis