Development and evaluation of 4-(pyrrolidin-3-yl)benzonitrile derivatives as inhibitors of lysine specific demethylase 1.

Mould, Daniel P

Development and evaluation of 4-(pyrrolidin-3-yl)benzonitrile derivatives as inhibitors of lysine specific demethylase 1. [electronic resource] - Bioorganic & medicinal chemistry letters 10 2017 - 4755-4759 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1464-3405

10.1016/j.bmcl.2017.08.052 doi


Binding Sites
Cell Line, Tumor
Drug Design
Enzyme Activation--drug effects
Enzyme Inhibitors--chemical synthesis
Histone Demethylases--antagonists & inhibitors
Humans
Inhibitory Concentration 50
Molecular Docking Simulation
Nitriles--chemical synthesis
Protein Structure, Tertiary
Pyrrolidines--chemistry
Stereoisomerism
Structure-Activity Relationship