Development of (4-Cyanophenyl)glycine Derivatives as Reversible Inhibitors of Lysine Specific Demethylase 1.
Mould, Daniel P
Development of (4-Cyanophenyl)glycine Derivatives as Reversible Inhibitors of Lysine Specific Demethylase 1. [electronic resource] - Journal of medicinal chemistry 10 2017 - 7984-7999 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1520-4804
10.1021/acs.jmedchem.7b00462 doi
Antineoplastic Agents--chemical synthesis
Biomarkers
Cell Line, Tumor
Computer Simulation
Drug Design
Drug Discovery
Enzyme Inhibitors--chemical synthesis
Ether-A-Go-Go Potassium Channels--drug effects
Glycine--analogs & derivatives
High-Throughput Screening Assays
Histone Demethylases--antagonists & inhibitors
Humans
Leukemia--drug therapy
Models, Molecular
Molecular Docking Simulation
Spiro Compounds--chemical synthesis
Structure-Activity Relationship
Tranylcypromine--analogs & derivatives
Development of (4-Cyanophenyl)glycine Derivatives as Reversible Inhibitors of Lysine Specific Demethylase 1. [electronic resource] - Journal of medicinal chemistry 10 2017 - 7984-7999 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1520-4804
10.1021/acs.jmedchem.7b00462 doi
Antineoplastic Agents--chemical synthesis
Biomarkers
Cell Line, Tumor
Computer Simulation
Drug Design
Drug Discovery
Enzyme Inhibitors--chemical synthesis
Ether-A-Go-Go Potassium Channels--drug effects
Glycine--analogs & derivatives
High-Throughput Screening Assays
Histone Demethylases--antagonists & inhibitors
Humans
Leukemia--drug therapy
Models, Molecular
Molecular Docking Simulation
Spiro Compounds--chemical synthesis
Structure-Activity Relationship
Tranylcypromine--analogs & derivatives