Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKβ/NF-κB/COX-2 signaling pathway.

Shrestha, Sandeep

Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKβ/NF-κB/COX-2 signaling pathway. [electronic resource] - International journal of oncology Oct 2017 - 1249-1260 p. digital

Publication Type: Journal Article

1791-2423

10.3892/ijo.2017.4097 doi


Animals
Antineoplastic Combined Chemotherapy Protocols--pharmacology
Cell Cycle Checkpoints--drug effects
Cell Line, Tumor
Cell Proliferation--drug effects
Curcumin--administration & dosage
Cyclooxygenase 2--metabolism
Cyclooxygenase 2 Inhibitors--pharmacology
Drug Synergism
Heterografts
Humans
I-kappa B Kinase--antagonists & inhibitors
Male
Melatonin--administration & dosage
Mice
Mice, Inbred BALB C
Mice, Nude
NF-kappa B--antagonists & inhibitors
Random Allocation
Signal Transduction--drug effects
Urinary Bladder Neoplasms--drug therapy