Dasatinib Reversibly Disrupts Endothelial Vascular Integrity by Increasing Non-Muscle Myosin II Contractility in a ROCK-Dependent Manner.

Kreutzman, Anna

Dasatinib Reversibly Disrupts Endothelial Vascular Integrity by Increasing Non-Muscle Myosin II Contractility in a ROCK-Dependent Manner. [electronic resource] - Clinical cancer research : an official journal of the American Association for Cancer Research Nov 2017 - 6697-6707 p. digital

Publication Type: Journal Article

1557-3265

10.1158/1078-0432.CCR-16-0667 doi


Actins--metabolism
Animals
Cell Line, Tumor
Dasatinib--administration & dosage
Endothelial Cells--drug effects
Gene Expression Regulation, Neoplastic--drug effects
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive--drug therapy
Mice
Molecular Motor Proteins--agonists
Myosin Heavy Chains
Wound Healing--drug effects
Xenograft Model Antitumor Assays
rho-Associated Kinases--genetics