Discovery and process development of a novel TACE inhibitor for the topical treatment of psoriasis.

Boiteau, Jean-Guy

Discovery and process development of a novel TACE inhibitor for the topical treatment of psoriasis. [electronic resource] - Bioorganic & medicinal chemistry 02 2018 - 945-956 p. digital

Publication Type: Journal Article

1464-3391

10.1016/j.bmc.2017.07.054 doi


ADAM17 Protein--antagonists & inhibitors
Administration, Topical
Animals
Drug Design
Enzyme Inhibitors--chemical synthesis
Female
Humans
Hydroxamic Acids--chemistry
Mice
Mice, Hairless
Microsomes, Liver--metabolism
Oxazolone--toxicity
Psoriasis--drug therapy
Skin Diseases--chemically induced
Solubility
Sulfonamides--chemical synthesis
Tumor Necrosis Factor-alpha--antagonists & inhibitors