Phthalazino[1,2-b]quinazolinones as p53 Activators: Cell Cycle Arrest, Apoptotic Response and Bak-Bcl-xl Complex Reorganization in Bladder Cancer Cells.

Zhang, Guo-Hai

Phthalazino[1,2-b]quinazolinones as p53 Activators: Cell Cycle Arrest, Apoptotic Response and Bak-Bcl-xl Complex Reorganization in Bladder Cancer Cells. [electronic resource] - Journal of medicinal chemistry 08 2017 - 6853-6866 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1520-4804

10.1021/acs.jmedchem.6b01769 doi


Antineoplastic Agents--chemical synthesis
Apoptosis--drug effects
Camptothecin--analogs & derivatives
Cell Line, Tumor
Cell Proliferation--drug effects
Drug Screening Assays, Antitumor
G2 Phase Cell Cycle Checkpoints--drug effects
Humans
Phthalazines--chemical synthesis
Quinazolinones--chemical synthesis
S Phase Cell Cycle Checkpoints--drug effects
Tumor Suppressor Protein p53--metabolism
Urinary Bladder Neoplasms--metabolism
bcl-2 Homologous Antagonist-Killer Protein--metabolism