The Axl kinase domain in complex with a macrocyclic inhibitor offers first structural insights into an active TAM receptor kinase.

Gajiwala, Ketan S

The Axl kinase domain in complex with a macrocyclic inhibitor offers first structural insights into an active TAM receptor kinase. [electronic resource] - The Journal of biological chemistry 09 2017 - 15705-15716 p. digital

Publication Type: Journal Article

1083-351X

10.1074/jbc.M116.771485 doi


Amino Acid Sequence
Binding Sites
Cell Membrane--enzymology
Drug Design
Enzyme Stability
Humans
Ligands
Macrocyclic Compounds--metabolism
Models, Molecular
Phosphorylation
Protein Binding
Protein Domains
Protein Kinase Inhibitors--metabolism
Proto-Oncogene Proteins--antagonists & inhibitors
Receptor Protein-Tyrosine Kinases--antagonists & inhibitors
Axl Receptor Tyrosine Kinase