A human tissue-based functional assay platform to evaluate the immune function impact of small molecule inhibitors that target the immune system.
St Pierre, Cristina
A human tissue-based functional assay platform to evaluate the immune function impact of small molecule inhibitors that target the immune system. [electronic resource] - PloS one 2017 - e0180870 p. digital
Publication Type: Journal Article
1932-6203
10.1371/journal.pone.0180870 doi
Chemokines--biosynthesis
Drug Evaluation, Preclinical--methods
Humans
Immune System--cytology
Killer Cells, Natural--drug effects
Leukocytes, Mononuclear--drug effects
Phagocytes--drug effects
Reactive Oxygen Species--metabolism
Small Molecule Libraries--pharmacology
T-Lymphocytes--drug effects
Toll-Like Receptors--metabolism
Transcriptome--drug effects
A human tissue-based functional assay platform to evaluate the immune function impact of small molecule inhibitors that target the immune system. [electronic resource] - PloS one 2017 - e0180870 p. digital
Publication Type: Journal Article
1932-6203
10.1371/journal.pone.0180870 doi
Chemokines--biosynthesis
Drug Evaluation, Preclinical--methods
Humans
Immune System--cytology
Killer Cells, Natural--drug effects
Leukocytes, Mononuclear--drug effects
Phagocytes--drug effects
Reactive Oxygen Species--metabolism
Small Molecule Libraries--pharmacology
T-Lymphocytes--drug effects
Toll-Like Receptors--metabolism
Transcriptome--drug effects