A human tissue-based functional assay platform to evaluate the immune function impact of small molecule inhibitors that target the immune system.

St Pierre, Cristina

A human tissue-based functional assay platform to evaluate the immune function impact of small molecule inhibitors that target the immune system. [electronic resource] - PloS one 2017 - e0180870 p. digital

Publication Type: Journal Article

1932-6203

10.1371/journal.pone.0180870 doi


Chemokines--biosynthesis
Drug Evaluation, Preclinical--methods
Humans
Immune System--cytology
Killer Cells, Natural--drug effects
Leukocytes, Mononuclear--drug effects
Phagocytes--drug effects
Reactive Oxygen Species--metabolism
Small Molecule Libraries--pharmacology
T-Lymphocytes--drug effects
Toll-Like Receptors--metabolism
Transcriptome--drug effects