Mechanism-based risk assessment strategy for drug-induced cholestasis using the transcriptional benchmark dose derived by toxicogenomics.

Kawamoto, Taisuke

Mechanism-based risk assessment strategy for drug-induced cholestasis using the transcriptional benchmark dose derived by toxicogenomics. [electronic resource] - The Journal of toxicological sciences 2017 - 427-436 p. digital

Publication Type: Journal Article

1880-3989

10.2131/jts.42.427 doi


Administration, Oral
Animals
Chlorpromazine--administration & dosage
Cholestasis--chemically induced
Cholesterol--biosynthesis
Cyclosporine--administration & dosage
Diclofenac--administration & dosage
Dose-Response Relationship, Drug
Flutamide--administration & dosage
Gene Expression
Humans
Imipramine--administration & dosage
Inflammation--genetics
Ketoconazole--administration & dosage
Liver
Methyltestosterone--administration & dosage
Oxidative Stress--genetics
Rats
Risk Assessment--methods
Sulindac--administration & dosage
Tamoxifen--administration & dosage
Toxicogenetics--methods