Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity.

LaMonte, Gregory M

Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity. [electronic resource] - Journal of medicinal chemistry 08 2017 - 6721-6732 p. digital

Publication Type: Journal Article

1520-4804

10.1021/acs.jmedchem.7b00671 doi


Antimalarials--chemical synthesis
Artemisinins--pharmacology
Dipeptides--chemical synthesis
Drug Design
Enzyme Assays
Hep G2 Cells
Humans
Molecular Docking Simulation
Oligopeptides--chemical synthesis
Plasmodium falciparum--drug effects
Proteasome Endopeptidase Complex--metabolism
Proteasome Inhibitors--chemical synthesis
Saccharomyces cerevisiae--drug effects