Structure-Based Approach To Identify 5-[4-Hydroxyphenyl]pyrrole-2-carbonitrile Derivatives as Potent and Tissue Selective Androgen Receptor Modulators.

Unwalla, Ray

Structure-Based Approach To Identify 5-[4-Hydroxyphenyl]pyrrole-2-carbonitrile Derivatives as Potent and Tissue Selective Androgen Receptor Modulators. [electronic resource] - Journal of medicinal chemistry 07 2017 - 6451-6457 p. digital

Publication Type: Journal Article

1520-4804

10.1021/acs.jmedchem.7b00373 doi


Anabolic Agents--chemical synthesis
Androgens--chemical synthesis
Animals
Crystallography, X-Ray
Hypothalamo-Hypophyseal System--drug effects
Male
Molecular Docking Simulation
Muscle, Skeletal--drug effects
Nitriles--chemical synthesis
Organ Size--drug effects
Organ Specificity
Prostate--drug effects
Pyrroles--chemical synthesis
Rats
Receptors, Androgen--metabolism
Seminal Vesicles--drug effects
Structure-Activity Relationship